A novel therapy for slowing down the progression of neurodegenerative diseases through a better understanding of the impact of environmental chemicals on neurodegeneration induction.
The incidence of neurodegenerative diseases (e.g. Alzheimer’s, Parkinson, multiple and amyotrophic lateral sclerose) is globally on the rise, and the increasing number of patients is challenging the existing medical care ressources. While these diseases are driven by genetics, there is also an important environmental input.
Despite decennia of intensive research early diagnose and effective therapy of these diseases is not yet possible. There are two important hurtles: 1. The underlying mechanisms of induction of neurodegeneration in humans are still not sufficiently understood; 2. The blood-brain barrier allows only chemicals with specific physicochemical charactereistics to enter the brain.
ToxGenSolutions BV envisages a project addressing the mechanistic aspects (Hurtle 1). -Omics approaches based on human stemcells and tissues are anticipated (i) to provide better and more relevant knowldege about the mechanisms affected by environmental factors and driving the induction of neurodegenerative diseases in humans, and (ii) to allow for the identification of human-relevant early biomarkers. Thus, the acquired knowledge offers new opportunities for the development of novel more accurate methods for early diagnosis of disease induction. In addition, alternative targets for novel anti-neurodegenerative drugs are anticipated to emerge from this project.