ToxGenSolution

Profiling your product through the complex multidimensional relationships between exposure, biological response, and human health outcome

For customized adverse outcome pathway-based animal-free testing and assessment strategies

The latest news from

ToxGenSolution

BREAKING NEWS

  • NEWSLETTER: INTERREG. PROJECT ”HERINNERINGEN” (”MEMORIES”), issue 3

    1. Optimization of in vitro exposure regimes to assure risk factor induced adverse effects in the absence of cytotoxicity.
    2. Hitting the road.

    Newsletter_072019

  • INVITATION TO THE 2019 SYMPOSIUM OF THE INTERREG. PROJECT ”HERINNERINGEN” (”MEMORIES”)

    The #interreg project #Herinneringen applies #animalfree approaches to understand the #adverseoutcomepathways (#AOP) driving sporadic #alzheimersdisease.

  • NEW TOOL FOR PREVENTIVE MEDICINE: DETECTING ALZHEIMER’S BEFORE IT BECOMES A DISEASE

    TGS is valorising a human relevant test method, based on a specific biomarker profile representing Alzheimer’s related neuronal processes before cell death occurs.

  • Finding Effortless Advice For Asian Women For Marriage

    There are lots of good reasons certainly where a great people may like to interact with Asian wives. There are factors that cause Fern?stliche women that some males just are not able to live with no. Asian females aren’t the same as West women in several points. There are some factors that arranged them besides and males will need to have these of those basic reasons. Regardless of the reason is which usually you’d probably want to offer an Hard anodized cookware woman inside your lifetime a number of selection of unique avenues the place you might take in order to meet all the Asian gal you may have always desired.

    Nonetheless, when you are a partner researching desperately to form the man appreciate you like before, it’s best to ensure you proceed effectively. You important thingto recognise is definitely your guy will progress away is it best to not attempt to retain his attention. If you think your soulmate has minimum fascination with you will, oahu is the time period for it to help you require some substantial steps to create for sure he doesn’t walk out of on the romance. However, exactly what you need additionally understand can be that presently there would be some mistakes and prepare challenges in your own human relationships. Just avoid committing those mistakes to have an ideal rapport. mybeautybrides

    Seeing Filipino, Hard anodized cookware Women

    Our next simple the reality is dieting. You need to shed pounds the two major components to success will be diets and workout. When you eat a lot of consumption of calories you will maintain your current weight; take a cheaper amount and you will then probably reduce weight. If you add working out for that strategy you’ll use-up more calories from fat to assist you to actually eat more or maybe change the mix of calories and use and lose fat. Simple.

    To assist rebuild and strengthen the relationship, begin remembering as you became a couple. Just how often you articulate on the mobile phone, send a voice message or text? Do you find it at one time a day or perhaps 50 situations, during conferences, at lunch break and in all the evening? A straightforward ‘I absolutely adore you’ text can make an enormous difference into a person and earn these people smile. ALRIGHT, so mailing a surgeon an interesting words when ever they’re in working surgery are probably not recommended, and so utilize comman sense!

    When i was kept heartbroken and emotionally distraught. My reactions were put into out, spilled along with the flooring, and trampled over. I just didn’t understand how to proceed out of many years of case “I like you” and basking on romantic memories spent by means of my a person like. Instead of declaring, “Oh well, God offers someone greater, ” I actually was weeping and expressing, “My your life is above! ”

    Tips about how to Make Much time Distance Marriages Work

    Effortless Secrets For https://www.theledger.com/entertainmentlife/20190212/dear-abby-is-starting-family-advisable-with-huge-age-gap-in-interracial-relationship Revealed Regularly I will discover someone tell me “I can’t imagine you happen to be seeing her! inch Naturally, my best next notion is: what is so challenging to imagine? While you will discover never some concrete reply, another assertions always suggest this individual is not satisfactory privately as people aren’t much the same. Either, it’s unlikely that any those people happen to be precisely the same; you happen to be you will and We are everybody designed for the reason, therefore, it will sound right that they can is not really similar seeing that me. And yet to hardly surprising, as I go around the avenue having a woman of one other run, the of repugnance that I collect from people including my personal contest is immeasurable. The world is certainly evolving, however they are all of us still swamped throughout the ancient ways? At this time, many people still might not prefer my methods, but subsequent to that afternoon, am I prohibited to pick out who I want to big day?

    Ways of life are handed down from straight down the relatives. There’re created for individuals to remain keeping that norms, community, and habits alive in a certain country as well as social group. Every country possess their own show of completely unique dating motions. From ages past, all of these Japanese seeing traditions experience evolved and grew to be even more modernized and complicated. Those also observed fundamental alterations where like and ambiance become the essential root of successful relationships.

  • THE INTERREG. PROJECT HERINNERINGEN (‘MEMORIES’) 2018 SYMPOSIUM ON EARLY BIOMARKERS FOR SPORADIC ALZHEIMERS

    THE INTERREG. PROJECT HERINNERINGEN (‘MEMORIES’) 2018 SYMPOSIUM ON EARLY BIOMARKERS FOR SPORADIC ALZHEIMERS

    27.11.2018 BY TOXGENSOLUTIONS BV
    Many thanks to the participants, and especially the speakers: Catherine Verfaillie (KULeuven (host)), Francesca Pistollato (EURLECVAM (invited speaker)), Annemie Ribbens (icometrix), Sebastiaan Engelborghs (UAntwerpen), Gerard Griffioen (reMYND), Jacco Briede and Rob Schlooz (UMaastricht) and Erwin L Roggen (ToxGenSolutions).

    The presentations will soon be available on toxgensolutions.eu.

  • TOXGENSOLUTIONS BV INVITES APPLICATIONS FOR A POSITION AS EXPERIENCED RESEARCHER, STARTING JANUARY 1, 2019.

    TOXGENSOLUTIONS BV INVITES APPLICATIONS FOR A POSITION AS EXPERIENCED RESEARCHER, STARTING JANUARY 1, 2019.

    16.11.2018 BY TOXGENSOLUTIONS BV

    POSITION FOR AN EXPERIENCED RESEARCHER

    ToxGenSolutions BV invites applications for a position as experienced researcher, starting January 1, 2019.

    ToxGenSolutions BV invites applications for a position as experienced researcher, starting January 1, 2019.

    You see you self as a researcher at a spin-off company based at the University of Maastricht with an ambition to expand. The research field is Neurodegeneration of the human brain, with focus on Alzheimer’s Disease (AD).

    The successful candidate will participate in an AD project supported by EU Interreg. Vlaanderen – Nederland, het Nederlands Ministerie van Economische Zaken, de Provincie Nederlands Limburg, Vlaams Agentschao Innoveren en Ondernemen (VLAIO) and the Provinces of Antwerpen and Vlaams Brabant.

    RESPONSIBILITIES AND TASKS:

    • Experimental planning of the project, problem solving and assuring compliance with the timelines of the project.
    • Laboratory work within the field of microRNA detection.
    • Performance of differential (epi-)genomics and pathway analyses.
    • Handling and reporting of experimental data.
    • Preparing microRNA profiles with diagnostic value for the market.

    QUALIFICATIONS:
    Applicants should have a PhD degree in (epi)genomics or equivalent with several years of experience.

    THE PROFILE OF THE IDEAL CANDIDATE:

    • You have experience with and enjoy laboratory work.
    • You have hands-on experience with state-of-the-art (epi-)genomics technologies.
    • Experience in bioinformatics will be considered an advantage.
    • You communicate fluently in English.
    • You can work with deadlines and pressure.
    • You are flexible, enthusiastic and responsible, with team spirit and excellent collaboration skills.

    WE OFFER:
    ToxGenSolutions BV offers a competitive scientific environment with the ambition to build a self-sustainable company applying front-edge non-animal toxicogenomics approaches on human health problems to provide the customer with genetic biomarker fingerprints for application in novel more accurate methods for diagnosis, novel tools for follow-up of disease progression or response to treatment in humans, and novel drug development.

    SALARY AND TERMS OF EMPLOYMENT:
    The appointment will be based on the current wage scales that are applied by the University of Maastricht. The position is for two years.

    FURTHER INFORMATION:
    For additional information about the position, please contact Erwin L Roggen (erwin.roggen@toxgensolutions.eu).

    You can read more about ToxGenSolutions BV on www.toxgensolutions.eu.

    APPLICATION PROCEDURE:
    Please submit your application no later than December 10, 2018 (Local time). Applications and enclosures received after the deadline will not be considered.

    Applications must be submitted as one PDF file containing all your materials in English. The file must include:

    • Application (cover letter)
    • CV
    • Diploma (MSc)

    All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.


  • YOU ARE HEREBY CORDIALLY INVITED TO THE FIRST ANNUAL MEETING ON NOVEMBER 23TH 2018 IN BUILDING ON1 AT THE KATHOLIEKE UNIVERSITY LEUVEN (HERESTRAAT 49, LEUVEN).

    YOU ARE HEREBY CORDIALLY INVITED TO THE FIRST ANNUAL MEETING ON NOVEMBER 23TH 2018 IN BUILDING ON1 AT THE KATHOLIEKE UNIVERSITY LEUVEN (HERESTRAAT 49, LEUVEN).

    23.10.2018 BY TOXGENSOLUTIONS BV

    The project ‘Herinneringen’ (‘Memories’) is about to finish the first year of its search for a cost-effective and minimally invasive method allowing for accurate diagnosis of (sporadic) Alzheimer’s disease (AD) before significant damage to the brain has occurred.

    You are hereby cordially invited to the first annual meeting on November 23th 2018 in building ON1 at the katholieke University Leuven (Herestraat 49, Leuven). Participation is free but registrations via the project web site (Menu, Contact) is required for practical reasons.

    The program can be downloaded from the same web site. Francesca Pistollato from the European Reference Laboratory – European Center for validation of Alternative methods to Animal Testing (EURL-ECVAM) will address the current challenges met by traditional AD research, and the need for the paradigm shift that forms the basis of the project ‘‘Herinneringen’ (‘Memories’).

    The project partners will present an overview of the different activities that are planned to meet the final goal, and progress will be reported where relevant. Special attention will be given to (i) the selection of the external risk factors for sporadic AD; (ii) the cell-based methods for identification of molecular and cellular processes that may be involved in the onset and early development of AD-related processes; (iii) the strategies to scientifically validated the human relevance of the identified potential biomarkers. See you November 23th.

  • FIRST NEWSLETTER OF THE PROJECT ”HERINNERINGEN” IS AVAILABLE

    FIRST NEWSLETTER OF THE PROJECT ”HERINNERINGEN” IS AVAILABLE

    Private-public funded innovation looking at Alzheimer’s disease initiation and development in a different way Newsletter: Interreg. Project ‘Herinneringen’ (”Memories”), Issue 1, 07.2018 (https://herinneringen.eu/en)

Higher relevance & revenues

HOW DOES IT WORK?

A VIRTUAL GENERIC GENOMICS-BASED PLATFORM THAT PROVIDES ANSWERS TO YOUR QUESTIONS ABOUT SAFETY AND EFFICACY OF YOUR PRODUCTS.

NEXT-GENERATION TOOLS

  • A systems-based technology platform for profiling the positive as well as negative impact of your product on biological response and human health at realistic concentrations and under relevant exposure regimes.
  • Our toolbox contains a breadth of technologies, systems, and pathways of toxicity and common nodes of toxicity developed by the Netherlands ToxicoGenomics Center (2008-2013).
  • The ToxGenSolutions toolbox is also useful for the identification of new opportunities for product development
  • The ToxGenSolutions toolbox is flexible, faster than traditional methods, more economical and more relevant for human safety and health.

FRONT-EDGE TECHNOLOGIES

  • ToxGenSolutions products are proprietary mechanism-based gene signatures for identification and classification of toxicants during screening, product development and safety assessment.
  • ToxGenSolutions provides a cutting-edge patchwork of test methods required for modern testing and assessment of compounds and products.
  • ToxGenSolutions builds on a virtual generic platform of leading test and technology developers providing novel technologies addressing key events in outcome pathways.

FOCUS ON YOUR NEEDS

  • ToxGenSolutions develops testing and assessment strategies for, and with, you to assure optimal coverage of your needs.
  • ToxGenSolutions develops strategies considering the nature of the test substance, the intended application, likely exposure routes, product development status and legislation.

An applied systems toxicology approach

FOR A SAFER FUTURE

THE WORKING HYPOTHESIS IS THAT THE COMBINATION OF EXPERTISE AND TECHNOLOGY FROM DIFFERENT DISCIPLINES WILL PROVIDE THE UNDERSTANDING OF HOW CHEMICALS INTERACT WITH BIOLOGICAL SYSTEMS THAT IS REQUIRED TO IMPROVE HUMAN SAFETY AND HEALTH.

ToxGensolutions
For customized adverse outcome pathway-based animal-free testing and assessment strategies

STILL ON THE TABLE

IMPROVING #ANIMALFREE TESTING AND ASSESSMENT BY COMBINING PHYSICO-CHEMICAL/STRUCTURAL ANALYSIS AND BIOLOGICAL PATHWAY ANALYSIS OF EXPOSED HUMAN CELLS AND TISSUEL.

(Q)SAR modeling is currently used to identify chemicals that are most likely to become a product,by having desired physico-chemical/structural characteristics (e.g. new leads for drug development), and by not exhibiting characteristics known to exert adverse effects in humans (e.g. hazard identification and safety testing).

It is currently not well established how well current (Q)SAR models discriminate chemicals with similar physico-chemical/structural characteristics but different in vivo outcome. This is a problem e.g. when in vivo animal models incorrectly indicate unsatisfactory efficacy or toxicity.

ToxGenSolutions BV envisages a novel quantitative systems biology approach for toxicity assessment linking physico-chemical characteristics of test compounds ((Q)SAR) with biological impact on cells/tissues, providing more accurate human health and safety where in vivo animal models fail.

A NOVEL THERAPY FOR SLOWING DOWN THE PROGRESSION OF NEURODEGENERATIVE DISEASES THROUGH A BETTER UNDERSTANDING OF THE IMPACT OF ENVIRONMENTAL CHEMICALS ON NEURODEGENERATION INDUCTION.

The incidence of neurodegenerative diseases (e.g. Alzheimer’s, Parkinson, multiple and amyotrophic lateral sclerose) is globally on the rise, and the increasing number of patients is challenging the existing medical care ressources.

While these diseases are driven by genetics, there is also an important environmental input. Despite decennia of intensive research early diagnose and effective therapy of these diseases is not yet possible. There are two important hurtles:

1. The underlying mechanisms of induction of neurodegeneration in humans are still not sufficiently understood;

2. The blood-brain barrier allows only chemicals with specific physicochemical charactereistics to enter the brain. ToxGenSolutions BV envisages a project addressing the mechanistic aspects (Hurtle 1). -Omics approaches based on human stemcells and tissues are anticipated (i) to provide better and more relevant knowldege about the mechanisms affected by environmental factors and driving the induction of neurodegenerative diseases in humans, and (ii) to allow for the identification of human-relevant early biomarkers. Thus, the acquired knowledge offers new opportunities for the development of novel more accurate methods for early diagnosis of disease induction. In addition, alternative targets for novel anti-neurodegenerative drugs are anticipated to emerge from this project.

INFORMATION

Do you have any questions to our services then you are welcome to contact us today. Call us or send an email and then we will reply as soon as possible.

CONTACT ADDRESS

ToxGenSolutions B.V.
Oxfordlaan 70
6229 EV Maastricht, The Netherlands

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