ToxGenSolutions

Toxicity tests, preclinical diagnostics and preventive therapeutics for three high impact pathologies triggered by environmental factors

(Epi-)genetic approaches addressing molecular initiation events and key events of adverse outcome pathways driving pathologies like neurodegeneration, cancer and immune-dysfunction

Breaking News and Latest Headlines

  • HUMAN SAMPLES SUPPORT THE RELEVANCE OF 20 ‘ENVIRONMENTAL’ miR’s

    Differentially expression analysis of human iPSCs derived neurons, and human brain slices, blood samples and cerebrospinal fluid from Alzheimer’s patients and control individuals has identified 20 potential biomarkers affecting processes and pathways that are relevant for Alzheimer’s disease progression.

    For further information: https://herinneringen.eu/nl

  • FIRST EVIDENCE FOR AN ‘ENVIRONMENTAL’ miR PROFILE FOR SPORADIC ALZHEIMER’S DISEASE

    After several months of lockdown, the Interreg. VL-NL supported project Herinneringen (Memories) was able to finalize the genetic analyses of the human iPSC derived neurons exposed to selected environmental risk factors and biopsies from Alzheimer’s patients and control individuals. Differential gene and pathway analysis revealed processes in patient derived iPSC and biopsies that were not seen in material from control individuals. Currently, 9 miR’s have caught our attention for further evaluation.

  • TOXGENSOLUTIONS RECOGNIZED AS VALUABLE PARTNER FOR INNOVATION AND ENTREPRENEURSHIP IN CHINA

  • DECEMBER 16TH, 2019: 2ND SYMPOSIUM OF THE INTERREG PROJECT ‘MEMORIES’.

    The symposium took place in the very attractive location called Promotie Zaal at the KULeuven which breaths the ancient atmosphere of scientific lectures and thesis defenses over the past centuries.

    During the scientific morning session researchers from the universities of Hasselt, Ghent, Brussels, Leuven and Antwerp provided an update on the current status of Alzheimer’s research in general and within our project. Our understanding of the mechanisms driving the development of Alzheimer’s disease is growing and may result in the discovery of diagnostics and therapeutics.

    The afternoon session targeted the general public. Kim Plasman (Stichting Alzheimer Onderzoek Belgium) Prof. Frans Verhey (University Maastricht), Prof. Sebastiaan Engelborghs (Universiteit of Antwerp) and Prof. Jos Kleinjans (University Maastricht) gave their more general overview about the current knowledge of this neurodegenerative disease. The Dutch journalist and publicist Hugo Borst closed the Symposium with sharing his personal experiences with his mother, who suffered from Alzheimer’s, reading touching passages from his latest book “Ach moedertje”.

  • TOXGENSOLUTIONS REPRESENTED THE INTERREG. PROJECT ”MEMORIES” DURING THE 29th ALZHEIMER’S EUROPE CONGRESS IN THE HAGUE.

    ToxGenSolutions presented a poster showing the approach adopted by the Interreg. project to develop a test for diagnosis of Alzheimer’s disease before it strikes (29th AEC_poster_PO.20.11). The congress was characterized by a high representation of technologies and technological developments that focusses on monitoring the patients. Presentations on scientific progress were limited, and focussing on the clinical phase of disease: ”Looking at Alzheimer’s through the peephole of dementia” as one of the speakers stated. Beside our poster, there was little, if at all, focus on the impact of environmental factors on induction and development of Alzheimer’s.  

  • THE INTERREG. PROJECT HERINNERINGEN (‘MEMORIES’) 2018 SYMPOSIUM ON EARLY BIOMARKERS FOR SPORADIC ALZHEIMERS

    THE INTERREG. PROJECT HERINNERINGEN (‘MEMORIES’) 2018 SYMPOSIUM ON EARLY BIOMARKERS FOR SPORADIC ALZHEIMERS

    27.11.2018 BY TOXGENSOLUTIONS BV
    Many thanks to the participants, and especially the speakers: Catherine Verfaillie (KULeuven (host)), Francesca Pistollato (EURLECVAM (invited speaker)), Annemie Ribbens (icometrix), Sebastiaan Engelborghs (UAntwerpen), Gerard Griffioen (reMYND), Jacco Briede and Rob Schlooz (UMaastricht) and Erwin L Roggen (ToxGenSolutions).

    The presentations will soon be available on toxgensolutions.eu.

  • TOXGENSOLUTIONS BV INVITES APPLICATIONS FOR A POSITION AS EXPERIENCED RESEARCHER, STARTING JANUARY 1, 2019.

    TOXGENSOLUTIONS BV INVITES APPLICATIONS FOR A POSITION AS EXPERIENCED RESEARCHER, STARTING JANUARY 1, 2019.

    16.11.2018 BY TOXGENSOLUTIONS BV

    POSITION FOR AN EXPERIENCED RESEARCHER

    ToxGenSolutions BV invites applications for a position as experienced researcher, starting January 1, 2019.

    ToxGenSolutions BV invites applications for a position as experienced researcher, starting January 1, 2019.

    You see you self as a researcher at a spin-off company based at the University of Maastricht with an ambition to expand. The research field is Neurodegeneration of the human brain, with focus on Alzheimer’s Disease (AD).

    The successful candidate will participate in an AD project supported by EU Interreg. Vlaanderen – Nederland, het Nederlands Ministerie van Economische Zaken, de Provincie Nederlands Limburg, Vlaams Agentschao Innoveren en Ondernemen (VLAIO) and the Provinces of Antwerpen and Vlaams Brabant.

    RESPONSIBILITIES AND TASKS:

    • Experimental planning of the project, problem solving and assuring compliance with the timelines of the project.
    • Laboratory work within the field of microRNA detection.
    • Performance of differential (epi-)genomics and pathway analyses.
    • Handling and reporting of experimental data.
    • Preparing microRNA profiles with diagnostic value for the market.

    QUALIFICATIONS:
    Applicants should have a PhD degree in (epi)genomics or equivalent with several years of experience.

    THE PROFILE OF THE IDEAL CANDIDATE:

    • You have experience with and enjoy laboratory work.
    • You have hands-on experience with state-of-the-art (epi-)genomics technologies.
    • Experience in bioinformatics will be considered an advantage.
    • You communicate fluently in English.
    • You can work with deadlines and pressure.
    • You are flexible, enthusiastic and responsible, with team spirit and excellent collaboration skills.

    WE OFFER:
    ToxGenSolutions BV offers a competitive scientific environment with the ambition to build a self-sustainable company applying front-edge non-animal toxicogenomics approaches on human health problems to provide the customer with genetic biomarker fingerprints for application in novel more accurate methods for diagnosis, novel tools for follow-up of disease progression or response to treatment in humans, and novel drug development.

    SALARY AND TERMS OF EMPLOYMENT:
    The appointment will be based on the current wage scales that are applied by the University of Maastricht. The position is for two years.

    FURTHER INFORMATION:
    For additional information about the position, please contact Erwin L Roggen (erwin.roggen@toxgensolutions.eu).

    You can read more about ToxGenSolutions BV on www.toxgensolutions.eu.

    APPLICATION PROCEDURE:
    Please submit your application no later than December 10, 2018 (Local time). Applications and enclosures received after the deadline will not be considered.

    Applications must be submitted as one PDF file containing all your materials in English. The file must include:

    • Application (cover letter)
    • CV
    • Diploma (MSc)

    All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.


  • YOU ARE HEREBY CORDIALLY INVITED TO THE FIRST ANNUAL MEETING ON NOVEMBER 23TH 2018 IN BUILDING ON1 AT THE KATHOLIEKE UNIVERSITY LEUVEN (HERESTRAAT 49, LEUVEN).

    YOU ARE HEREBY CORDIALLY INVITED TO THE FIRST ANNUAL MEETING ON NOVEMBER 23TH 2018 IN BUILDING ON1 AT THE KATHOLIEKE UNIVERSITY LEUVEN (HERESTRAAT 49, LEUVEN).

    23.10.2018 BY TOXGENSOLUTIONS BV

    The project ‘Herinneringen’ (‘Memories’) is about to finish the first year of its search for a cost-effective and minimally invasive method allowing for accurate diagnosis of (sporadic) Alzheimer’s disease (AD) before significant damage to the brain has occurred.

    You are hereby cordially invited to the first annual meeting on November 23th 2018 in building ON1 at the katholieke University Leuven (Herestraat 49, Leuven). Participation is free but registrations via the project web site (Menu, Contact) is required for practical reasons.

    The program can be downloaded from the same web site. Francesca Pistollato from the European Reference Laboratory – European Center for validation of Alternative methods to Animal Testing (EURL-ECVAM) will address the current challenges met by traditional AD research, and the need for the paradigm shift that forms the basis of the project ‘‘Herinneringen’ (‘Memories’).

    The project partners will present an overview of the different activities that are planned to meet the final goal, and progress will be reported where relevant. Special attention will be given to (i) the selection of the external risk factors for sporadic AD; (ii) the cell-based methods for identification of molecular and cellular processes that may be involved in the onset and early development of AD-related processes; (iii) the strategies to scientifically validated the human relevance of the identified potential biomarkers. See you November 23th.

Human Safety and Health based on Human Relevant (Epi-)Genetics

A VIRTUAL GENERIC (EPI-)GENETICS-BASED PLATFORM THAT PROVIDES ANSWERS TO YOUR QUESTIONS ABOUT SAFETY AND EFFICACY OF YOUR PRODUCTS.

NEXT-GENERATION TOOLS

  • A systems-based technology platform for profiling the positive as well as negative impact of compounds and product on (patho-)physiological responses and human health at realistic concentrations and under relevant exposure regimes.

  • Our toolbox contains a breadth of technologies, systems, and pathways and common nodes of toxicity and pathology.

  • The available toolbox is useful for the identification of new opportunities for product development in the chemical, cosmetic, food, diagnostics and pharmaceutical sector.

  • The toolbox is flexible, faster than traditional methods, more economical and more relevant for human safety and health.

FRONT-EDGE TECHNOLOGIES

  • ToxGenSolutions products are proprietary mechanism-based (epi-)genetic signatures for identification and classification of new leads and toxicants during screening, product development and safety assessment.

  • ToxGenSolutions provides a front-edge patchwork of test methods required for modern testing and assessment of compounds and products through tight collaboration with front-runners in the area of human tissue development.

  • ToxGenSolutions exploits the (epi-)genetic data to develop diagnostics for high impact pathologies (e.g. neurodegenerative diseases, cancer, immuno-dysfunction) in a preclinical stage.

FOCUS ON YOUR NEEDS

  • ToxGenSolutions develops testing and assessment strategies for, and with, you to assure optimal coverage of your needs.
  • ToxGenSolutions develops strategies considering the nature of the test substance, the intended application, likely exposure routes, product development status and legislation.

Engaging front-runners in a multidisciplinary approach for a safer future

Future perspectives

Diagnostic devices for high impact pathologies, triggered by environmental risk factors and life style, incorporating artificial intelligence based on big.

Advanced in vitro platform for personalized cancer medicine and treatment using intestinal human tissue, representing a very fast method to test individual  responses to a drug and to determine the safe but effective dosage.

New therapeutic targets allowing for treatment of neurodegenerative diseases in a preclinical stage.

The impact of inflammatory signals on cell-cell communication in the brain using state-of-the-art in vitro methods.

An ontology-driven and artificial intelligence-based strategy, linked with a battery of in vitro assays and in silico tools for hazard prediction, combined with tailored exposure assessment for human risk assessment.

INFORMATION

Do you have any questions to our services then you are welcome to contact us today. Call us or send an email and then we will reply as soon as possible.

CONTACT ADDRESS

ToxGenSolutions B.V.
Oxfordlaan 70
6229 EV Maastricht, The Netherlands

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