1. Optimization of in vitro exposure regimes to assure risk factor induced adverse effects in the absence of cytotoxicity.
2. Hitting the road.
The #interreg project #Herinneringen applies #animalfree approaches to understand the #adverseoutcomepathways (#AOP) driving sporadic #alzheimersdisease.
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27.11.2018 BY TOXGENSOLUTIONS BV
Many thanks to the participants, and especially the speakers: Catherine Verfaillie (KULeuven (host)), Francesca Pistollato (EURLECVAM (invited speaker)), Annemie Ribbens (icometrix), Sebastiaan Engelborghs (UAntwerpen), Gerard Griffioen (reMYND), Jacco Briede and Rob Schlooz (UMaastricht) and Erwin L Roggen (ToxGenSolutions).
The presentations will soon be available on toxgensolutions.eu.
ToxGenSolutions BV invites applications for a position as experienced researcher, starting January 1, 2019.
ToxGenSolutions BV invites applications for a position as experienced researcher, starting January 1, 2019.
You see you self as a researcher at a spin-off company based at the University of Maastricht with an ambition to expand. The research field is Neurodegeneration of the human brain, with focus on Alzheimer’s Disease (AD).
The successful candidate will participate in an AD project supported by EU Interreg. Vlaanderen – Nederland, het Nederlands Ministerie van Economische Zaken, de Provincie Nederlands Limburg, Vlaams Agentschao Innoveren en Ondernemen (VLAIO) and the Provinces of Antwerpen and Vlaams Brabant.
RESPONSIBILITIES AND TASKS:
Applicants should have a PhD degree in (epi)genomics or equivalent with several years of experience.
THE PROFILE OF THE IDEAL CANDIDATE:
ToxGenSolutions BV offers a competitive scientific environment with the ambition to build a self-sustainable company applying front-edge non-animal toxicogenomics approaches on human health problems to provide the customer with genetic biomarker fingerprints for application in novel more accurate methods for diagnosis, novel tools for follow-up of disease progression or response to treatment in humans, and novel drug development.
SALARY AND TERMS OF EMPLOYMENT:
The appointment will be based on the current wage scales that are applied by the University of Maastricht. The position is for two years.
For additional information about the position, please contact Erwin L Roggen (firstname.lastname@example.org).
You can read more about ToxGenSolutions BV on www.toxgensolutions.eu.
Please submit your application no later than December 10, 2018 (Local time). Applications and enclosures received after the deadline will not be considered.
Applications must be submitted as one PDF file containing all your materials in English. The file must include:
All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.
The project ‘Herinneringen’ (‘Memories’) is about to finish the first year of its search for a cost-effective and minimally invasive method allowing for accurate diagnosis of (sporadic) Alzheimer’s disease (AD) before significant damage to the brain has occurred.
You are hereby cordially invited to the first annual meeting on November 23th 2018 in building ON1 at the katholieke University Leuven (Herestraat 49, Leuven). Participation is free but registrations via the project web site (Menu, Contact) is required for practical reasons.
The program can be downloaded from the same web site. Francesca Pistollato from the European Reference Laboratory – European Center for validation of Alternative methods to Animal Testing (EURL-ECVAM) will address the current challenges met by traditional AD research, and the need for the paradigm shift that forms the basis of the project ‘‘Herinneringen’ (‘Memories’).
The project partners will present an overview of the different activities that are planned to meet the final goal, and progress will be reported where relevant. Special attention will be given to (i) the selection of the external risk factors for sporadic AD; (ii) the cell-based methods for identification of molecular and cellular processes that may be involved in the onset and early development of AD-related processes; (iii) the strategies to scientifically validated the human relevance of the identified potential biomarkers. See you November 23th.
Private-public funded innovation looking at Alzheimer’s disease initiation and development in a different way Newsletter: Interreg. Project ‘Herinneringen’ (”Memories”), Issue 1, 07.2018 (https://herinneringen.eu/en)
(Q)SAR modeling is currently used to identify chemicals that are most likely to become a product,by having desired physico-chemical/structural characteristics (e.g. new leads for drug development), and by not exhibiting characteristics known to exert adverse effects in humans (e.g. hazard identification and safety testing).
It is currently not well established how well current (Q)SAR models discriminate chemicals with similar physico-chemical/structural characteristics but different in vivo outcome. This is a problem e.g. when in vivo animal models incorrectly indicate unsatisfactory efficacy or toxicity.
ToxGenSolutions BV envisages a novel quantitative systems biology approach for toxicity assessment linking physico-chemical characteristics of test compounds ((Q)SAR) with biological impact on cells/tissues, providing more accurate human health and safety where in vivo animal models fail.
The incidence of neurodegenerative diseases (e.g. Alzheimer’s, Parkinson, multiple and amyotrophic lateral sclerose) is globally on the rise, and the increasing number of patients is challenging the existing medical care ressources.
While these diseases are driven by genetics, there is also an important environmental input. Despite decennia of intensive research early diagnose and effective therapy of these diseases is not yet possible. There are two important hurtles:
1. The underlying mechanisms of induction of neurodegeneration in humans are still not sufficiently understood;
2. The blood-brain barrier allows only chemicals with specific physicochemical charactereistics to enter the brain. ToxGenSolutions BV envisages a project addressing the mechanistic aspects (Hurtle 1). -Omics approaches based on human stemcells and tissues are anticipated (i) to provide better and more relevant knowldege about the mechanisms affected by environmental factors and driving the induction of neurodegenerative diseases in humans, and (ii) to allow for the identification of human-relevant early biomarkers. Thus, the acquired knowledge offers new opportunities for the development of novel more accurate methods for early diagnosis of disease induction. In addition, alternative targets for novel anti-neurodegenerative drugs are anticipated to emerge from this project.
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